A Canine Arthroscopic Anterior Cruciate Ligament Reconstruction Model for Study of Synthetic Augmentation of Tendon Allografts | Semantic Scholar (2024)

This review includes a discussion on comparative knee anatomy, technical considerations including types of tendon grafts employed amongst the small laboratory species, and common laboratory evaluative methods used to study healing and outcomes after ACL reconstruction in small laboratory animals.

Robust tendon grafts combined with a synthetic internal brace and platelet-rich plasma (PRP) may allow for more rapid and robust tendon–bone healing and graft “ligamentization,” which protects the graft from early failure and rapid OA development that can plague commonly-used allografts.

Novel graft constructs and surgical implantation and fixation techniques allow for consistent surgical reconstruction of all major ligaments in MLKIs such that socket and tunnel overlap can be consistently avoided.

The effectiveness of ACL reinforcedreconstruction with autologous hamstring tendon combined with anchor suture band is satisfactory, it has better initial strength and joint stability, and is more conducive to early postoperative functional exercise and functional recovery of knee joint.

There is a lack of data to comprehensively comment upon the clinical superiority of the use of internal augmentation in both ACL reconstruction and ACL repair, but a meta-analysis of the retear rates and clinical outcome score revealed similar outcomes between suture tape augmented and nonaugmented groups.

Although SA did not reduce the retear rate, and infection and DVT rates did not differ between study groups, superior improvement of PROMs in SA approach, leverages this method for ACLR.

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The data suggest that this canine model was able to overcome the major limitations of large animal models used for translational research in ACL reconstruction and closely follow clinical aspects of human ACL reconstruction.

This finding indicates that interference fit fixation of a soft-tissue graft may additionally alter the mechanical properties of the graft in the early remodeling stage because of a possible tissue compromise at the screw insertion site.

Using this systematic translational approach, “bio‐enhanced” ACL repair has been advanced to the point where it may become an option for future treatment of acute ACL injuries and the prevention of subsequent post‐traumatic osteoarthritis associated with this injury.

The TightRope CCL technique is safe and effective and can be considered an appropriate surgical option as part of the overall treatment plan for CCL deficiency in dogs and was associated with shorter anesthesia and surgery times as well as a lower complication rate.

The sheep ACL reconstruction model showed predominant intrinsic fibroblast necrosis in the tendon autograft until 12 weeks, and it was suggested that vigorous activity should not be permitted for patients in the early periods after ACL reconstruction using semitendinosus tendon autogs, which are necrotized and weakened after surgery.

The rupture rates of both LARS and ABC grafts were both high, however, the LARS ligament provided significantly better survivorship compared with the ABC ligament at short- to midterm follow-up (95% CI).

Initial graft slippage is lower with GG versus BP extracortical hamstring graft tibial fixation, and postoperative recovery and joint stability are more consistent with the GG, which supports the GG as an alternative to extracordical tibia-hamstring hamstring graft fixation that has procedural advantages over current implants and reduces graft failure from slipperage.

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